Description
Kisspeptin-10 is a C-terminal decapeptide fragment of the KiSS-1 gene product metastin. It is a potent agonist of the GPR54 receptor and plays a central role in the regulation of the hypothalamic-pituitary-gonadal axis. Research applications include studies of reproductive endocrinology and neuroendocrine signaling.
Quick Facts
- Category
- Hormone
- Molecular Weight
- 1,302.5 Da
- CAS Number
- 374675-21-5
- Amino Acids
- 10
- Storage
- Store lyophilized at -20°C. Reconstituted solutions at 4°C for up to 7 days.
- Solubility
- Soluble in water and aqueous buffers
A CAS number uniquely identifies a chemical substance.
g/mol describes mass per mole; Da describes the mass of a single molecule. A vendor’s mg value is the mass in the offered package.
Amino acids are the building blocks of a peptide; the count gives their number.
Vendors for Kisspeptin
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Listed vendors2
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| Status | Visit Site | ||
|---|---|---|---|
$5.78/mg$5.20/mg10 mg | Verified | ||
$10.80/mgFrom $10.26/mg10 mg | Verified |
Research Summary
Kisspeptin-10 has been extensively studied in reproductive endocrinology. Research demonstrates its role as the primary upstream regulator of GnRH neurons, with implications for understanding puberty onset, fertility regulation, and hypothalamic-pituitary-gonadal axis modulation. Multiple clinical trials have investigated its diagnostic potential in reproductive disorders.
Mechanism of Action
Binds to and activates the GPR54 (KISS1R) receptor on GnRH neurons in the hypothalamus, triggering the release of gonadotropin-releasing hormone (GnRH). This stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion from the anterior pituitary.
Known Research Compound Interactions
Based on published preclinical research literature
For laboratory research reference only. Not for human consumption. Interaction data derived from preclinical studies and receptor binding profiles. Always consult primary literature for specific research protocols.
Interaction assessments based on receptor binding affinity, signaling pathway analysis, and published preclinical data. For laboratory research use only. Not for human consumption.
For laboratory research use only. Not for human consumption.