AOD 9604: Complete Research Guide & Chemical Profile

AOD 9604, also known as Anti-Obesity Drug 9604 or Tyr-hGH Frag 177-191, is a synthetic peptide fragment derived from human growth hormone (hGH). This modified peptide consists of the amino acid sequence 177-191 of hGH with an additional tyrosine residue at the N-terminus, resulting in the complete sequence YLRIVQCRSVEGSCGF.

With a molecular weight of 1815.08 Da, AOD 9604 represents a carefully engineered peptide that maintains specific biological properties of the parent growth hormone while exhibiting distinct characteristics. The peptide is synthesized to research-grade standards with purity levels typically exceeding 98%, making it suitable for controlled laboratory investigations.

The development of AOD 9604 emerged from research into growth hormone's lipolytic properties, specifically targeting the C-terminal region responsible for fat metabolism without the growth-promoting effects associated with the full hormone. This selective modification has made it a compound of interest in metabolic research studies.

Initial research into AOD 9604 was conducted by Metabolic Pharmaceuticals in Australia, focusing on its potential applications in metabolic studies. Early investigations examined the peptide's ability to stimulate lipolysis in laboratory settings while avoiding the diabetogenic effects associated with full-length growth hormone.

Research studies have investigated AOD 9604's effects on adipose tissue metabolism in various experimental models. Laboratory findings suggest that the peptide may influence fat cell metabolism through specific receptor interactions, though the exact mechanisms continue to be studied in research environments.

Clinical research phases examined the peptide's safety profile and biological activity in controlled settings. These studies provided valuable data on the peptide's pharmacokinetic properties, including its relatively short half-life of approximately 30 minutes, which influences experimental design considerations in research applications.

More recent research has expanded to explore AOD 9604's potential applications beyond metabolic studies, including investigations into tissue repair and regenerative processes in laboratory models. These emerging research areas continue to provide insights into the peptide's diverse biological activities.

Research indicates that AOD 9604 exerts its effects through selective interaction with growth hormone receptors, specifically targeting pathways involved in lipid metabolism. The peptide appears to stimulate lipolysis through activation of hormone-sensitive lipase in adipose tissue, based on laboratory studies.

Unlike full-length growth hormone, AOD 9604 does not appear to significantly affect glucose metabolism or stimulate IGF-1 production in research models. This selective activity profile makes it particularly interesting for studies focused on lipid metabolism without the confounding effects of growth promotion.

Laboratory investigations suggest that the peptide may also influence mitochondrial function and cellular energy metabolism. Research has indicated potential effects on beta-oxidation processes and fatty acid utilization in experimental settings, though these mechanisms require further investigation.

The addition of tyrosine to the N-terminus appears to enhance the peptide's stability and biological activity compared to the native hGH fragment. This modification may contribute to improved receptor binding affinity and resistance to enzymatic degradation in research applications.

Research-grade AOD 9604 is typically synthesized to achieve purity levels of ≥98% as determined by high-performance liquid chromatography (HPLC). This high purity standard ensures consistency and reliability in laboratory applications, minimizing potential confounding variables from impurities.

Quality control measures for AOD 9604 include mass spectrometry verification to confirm molecular weight and amino acid sequence accuracy. These analytical methods are essential for validating peptide identity and ensuring research reproducibility across different laboratory settings.

AOD 9604 demonstrates optimal stability when stored as a lyophilized powder at temperatures below -20°C. Under these conditions, the peptide maintains its structural integrity and biological activity for extended periods, typically remaining stable for 2-3 years when properly stored.

Once reconstituted, the peptide solution should be stored at 2-8°C and used within a specified timeframe to maintain research quality. The peptide's relatively short half-life of approximately 30 minutes necessitates careful timing considerations in experimental protocols.

Solubility characteristics show that AOD 9604 is readily soluble in sterile water or appropriate buffer systems commonly used in research applications. The peptide maintains stability in physiological pH ranges, making it suitable for various in vitro and in vivo research models.

Researchers can access verified suppliers and third-party tested batches of AOD 9604 through ChemVerify's comprehensive database. The platform provides detailed analytical certificates and vendor verification information to ensure research-grade quality standards are met.

ChemVerify's AOD 9604 product page at /product/aod-9604 features multiple verified suppliers offering various quantities and purities suitable for different research applications. Each listing includes comprehensive analytical data, storage recommendations, and supplier credentials to support informed procurement decisions.

The platform's vendor verification process ensures that all listed suppliers maintain appropriate quality management systems and provide authentic research-grade peptides. This verification system helps researchers access reliable sources while maintaining the integrity of their scientific investigations.

What research applications is AOD 9604 commonly used for? Laboratory studies primarily focus on metabolic research, particularly investigations into lipid metabolism and adipose tissue function. The peptide is also used in studies examining energy metabolism, mitochondrial function, and cellular metabolic pathways in various experimental models.

How does AOD 9604 differ from full-length growth hormone in research applications? Research indicates that AOD 9604 provides selective lipolytic effects without the growth-promoting and diabetogenic properties associated with complete growth hormone. This selectivity makes it valuable for studies specifically targeting fat metabolism without confounding growth-related variables.

What experimental models are commonly used with AOD 9604 research? Studies typically employ in vitro cell culture systems, particularly adipocyte cultures, as well as various animal models for metabolic research. The choice of experimental model depends on the specific research objectives and the biological pathways being investigated.

What analytical methods are used to verify AOD 9604 identity and purity? Standard analytical techniques include HPLC for purity determination, mass spectrometry for molecular weight confirmation, and amino acid analysis for sequence verification. These methods ensure research-grade quality and support reproducible experimental results.

How should reconstituted AOD 9604 be handled in laboratory settings? Reconstituted peptide should be stored at 2-8°C and used according to experimental protocols within recommended timeframes. Given its 30-minute half-life, timing considerations are crucial for maintaining biological activity during research procedures.

What factors should be considered when designing experiments with AOD 9604? Key considerations include the peptide's short half-life, optimal storage conditions, appropriate concentration ranges for specific research applications, and potential interactions with other experimental variables. Proper experimental design ensures reliable and reproducible research outcomes.

Explore detailed chemical profiles and research guides for compounds discussed in this article:

• HGH Fragment 176-191: Complete Research Guide → /learn/hgh-fragment-176-191
• Ipamorelin: Complete Research Guide → /learn/ipamorelin

• Read more: RFK Jr. Signals Reversal of Peptide Ban: 14 of 19 Restricted Compounds May Return → https://www.chemverify.com/learn/rfk-jr-signals-reversal-of-peptide-ban-14-of-19-restricted-compounds-may-return
• Read more: Peptide Combinations: Compatibility Research & Evidence Assessment → https://www.chemverify.com/learn/peptide-combinations
• Read more: Complete Peptide Solubility Guide: Solutions for Research Success → https://www.chemverify.com/learn/complete-peptide-solubility-guide-solutions-for-research-success
• Read more: Amino Acid Analysis for Peptides: Complete Guide to Verification Methods → https://www.chemverify.com/learn/amino-acid-analysis-for-peptides-complete-guide-to-verification-methods
• Read more: GMP Peptide Manufacturing: Standards and Quality Control Guidelines → https://www.chemverify.com/learn/gmp-peptide-manufacturing-standards-and-quality-control-guidelines